Tumor suppressor p53 meets microRNAs
نویسندگان
چکیده
منابع مشابه
Cancer genetics: Tumor suppressor meets oncogene
The adenomatous polyposis coli (APC) tumor suppressor protein is inactivated by mutations in the majority of colorectal cancers. A recent study has revealed that alterations in the APC signaling pathway can result in the transcriptional activation of the c-MYC gene.
متن کاملThe guardian's little helper: microRNAs in the p53 tumor suppressor network.
Several microRNAs (miRNAs) have been implicated in tumor development based on both changes in their expression patterns and gene structural alterations in human tumors. However, we are only now beginning to see how miRNAs interact with classic oncogene and tumor suppressor mechanisms. Several recent studies have implicated the miR-34 family of miRNAs in the p53 tumor suppressor network. The exp...
متن کاملTumor suppressor p53: regulation and function.
The p53 protein is a transcription factor involved in maintaining genomic integrity by controlling cell cycle progression and cell survival. Mutations in p53 are the most frequently seen genetic alterations in human cancer. The function of p53 is critical to the way many cancer treatments kill cells because radiotherapy and chemotherapy act in part by triggering programmed cell death in respons...
متن کاملP53 is a tumor suppressor gene
Arnold J. Levine, 1. Cathy A. Finlay, 2 and Philip W. Hinds 3 1Institute for Advanced Study Einstein Drive Princeton, New Jersey 08540 and Cancer Institute of New Jersey 195 Little Albany St. New Brunswick, New Jersey 08903 2 Department of High Throughput Biology GlaxoSmithKline 5 Moore Drive Research Triangle Park, North Carolina 27709 3Harvard Medical School Department of Pathology Armenise 4...
متن کاملRegulation of the p53 tumor suppressor protein.
Mutations in the p53 tumor suppressor gene occur in about 50% of all human tumors, making it the most frequent target for genetic alterations in cancer (for recent reviews on p53 see Refs. 1–5). Such mutations probably facilitate carcinogenesis primarily through abrogating the tumor suppressor activities of the wild type p53 protein, although at least some forms of tumor-associated mutant p53 p...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Molecular Cell Biology
سال: 2011
ISSN: 1674-2788
DOI: 10.1093/jmcb/mjq040